I usually base it around the challenge I’m doing for the tome but if it’s just for fun I like doing a hybrid of saving and looping killers. My general set up usually is Spine Chill, We're Gonna Live Forever, Resilience and Adrenaline. If I’m going for those sweet meme builds than I change out Adrenaline for Break Out and bring in a sabo tool box.
I base mine on “What type of Character do I wanna be during this match” . Like do I wanna help people off the hook, be the distraction, or be a person that gets a generator done. You can guess which type I am with one of my perk builds: Spine Chill , Balanced Landing, Adrenaline, and Windows Of Opportunity
The build depends on what you want to do. You want to be gen focused? Or run the killer for 6 hours ? Or be a ghost ? If you want a build that makes a bit of everything, I would suggest dead hard, autotdidact, DS and adrenawin.
I base my builds around each character own perks. I never use a "1 build fits all" approach.