No perks is best perks. Lol. Jk it depends on how you play
This is a opinion based answer but I would say the best perks would be Adrenalin (Meg Perk), Unbreakable (Bill Perk) and any exhaustion perk of your choosing so long as you can use it to extend the loop or escape. The last perk is always optional for what you might be feeling but Autodidact (Adam Perk) or Borrowed Time (Bill Perk) are other two good perks.
Iron Will has to be in there, defo in red ranks
In my experience; an exhaustion perk, resilience, spine chill and iron will.
For me Adrenaline-resilience-spine chill-DS